研究業績

原著論文

2023

  1. Kikuo Komori, Shinnosuke Takumi, Kiichi Kato, Kazuya Matsumoto, Kohei Shiraishi, Hiroshi Kimura, Kazutake Takada,"Direct electron transfer kinetics of histamine dehydrogenase at air plasma-treated graphite nanofibers",Journal of Electroanalytical Chemistry,vol.943,943 117621-117621,08.2023[link]
  2. Xuemin Feng, Takafumi Matsumura, Yuki Yamashita, Takuya Sato, Kiyoshi Hashimoto, Hisakazu Odaka, Yoshinori Makino, Yuki Okada, Hiroko Nakamura, Hiroshi Kimura, Teruo Fujii, Takehiko Ogawa,"In vitro spermatogenesis in isolated seminiferous tubules of immature mice"PLOS ONE,vol.18(4), e0283773-e0283773,04.2023[link]
  3. Yuka Sakata, Hong Zhang, Akiko Sugiyama, Nami Motosugi, Hiroshi Kimura, Yosuke Okamura, Atsushi Fukuda,"Nanosheet coating improves stability of human pluripotent stem cell culture on glass substrates",Biochemical and Biophysical Research Communications,vol.650,55-61,01.2023[link]
  4. Kotaro Doi, Hiroshi Kimura, Soo Hyeon Kim, Shohei Kaneda, Takehiko Wada, Tetsuhiro Tanaka, Akira Shimizu, Takanori Sano, Masatomo Chikamori, Marie Shinohara, Yukiko T Matsunaga, Masaomi Nangaku, Teruo Fujii,"Enhanced podocyte differentiation and changing drug toxicity sensitivity through pressure controlled mechanical filtrating stress on a glomerulus-on-a-chip"Lab on a Chip,2023[link]

 

2022

  1. *K. Komori, M. Usui, K. Hatano, Y. Hori, K. Hirono, D. Zhu, F. Tokito, M. Nishikawa, Y. Sakai, H. Kimura,"In vitro enzymatic electrochemical monitoring of glucose metabolism and production in rat primary hepatocytes on highly O2 permeable plates",Bioelectrochemistry,vol.143,107972-1-8,2022.[link]
  2. K. Doi, H. Kimura, Y. Matsunaga, T. Fujii, *M. Nangaku,"Glomerulus-on-a-chip: Current insights and future potential towards recapitulating selectively permeable filtration systems",International Journal of Nephrology and Renovascular Disease,vol.15,85-101,2022.[link]
  3. *Y. Arata, I. Shiga, Y. Ikeda, P. Jurica, H. Kimura, K. Kiyono, Y. Sako,"Insulin signaling shapes fractalscaling of C. elegans behavior",Scientific reports,vol.12,10481,2022.[link]

2021

  1. P. V. Hauser, H. Chang, M. Nishikawa, H. Kimura, N. Yanagawa, *M. Hamon,"Bioprinting Scaffolds for Vascular Tissues and Tissue Vascularization",Bioengineering(Basel.),vol.8,No.11,178,2021.[link]
  2. 榛葉健汰, 二瓶渉, 中村寛子, 河西巧, 後藤智美, 荒川大, 稲村恒亮, 西川昌輝, 加藤将夫, 酒井康行, 木村啓志,"オンチップポンプ型多臓器Microphysiological system(MPS)を用いた臓器間相互作用の評価",化学とマイクロ・ナノシステム,vol.20.No.2,52-53,2021.
  3. K. Shinha, W. Nihei, H. Nakamura, T. Goto, T. Kawanishi, N. Ishida, N. Yamazaki, Y. Imakura, S. Mima, K. Inamura, H. Arakawa, M. Nishikawa, Y. Kato, Y. Sakai, *H. Kimura,"A Kinetic-Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-based Multi-Organ Microphysiological Systems",Micromachines,vol12,No.9,1007,2021. [link]
  4. A. Otomo, S. Ono, K. Sato, S. Mitsui, K. Shimakura, *H. Kimura, *S. Hadano,"High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device",Neuroscience Research,vol.174,46-52,2021. [link]
  5. K. Doi, H. Kimura, T. Wada, T. Tanaka, K. Hiromura, M. A. Saleem, R. Inagi, M. Nangaku, *T. Fujii,"A novel method for successful induction of interdigitating process formation in conditionally immortalized podocytes from mice, rats, and humans",Biochemical and Biophysical Research Communications,vol.570,47-52,2021. [link]
  6. M. Shinohara, H. Arakawa, Y. Oda, N. Shiraki, S. Sugiura, T. Nishiuchi, T. Satoh, K. Iino, S. Leo, Y. Kato, K. Araya, T. Kawanishi, T. Nakatsuji, M. Mitsuta, K. Inamura, T. Goto, K. Shinha, W. Nihei, K. Komori, M. Nishikawa, S. Kume, Y. Kato, T. Kanamori, Y. Sakai,* H. Kimura, "Coculture with hiPS‑derived intestinal cells enhanced human hepatocyte functions in a pneumatic‑pressure‑driven two‑organ microphysiological system", Scientific reports, vol.11, 5437, 2021. [link]
  7. T. Matsumura, T. Sato, T. Abe, H. Sanjo, K. Katagiri, H. Kimura, T. Fujii, H. Tanaka, M. Hirabayashi,* T. Ogawa, "Rat in vitro spermatogenesis promoted by chemical supplementations and oxygen-tension control", Scientific reports, vol.11, 3458, 2021. [link]

2020

  1. S. Mise, S. Shibagaki, S. Nishikawa, H. Nakamura, H. Kimura, *A. Takamatsu, "Diversity in self-organized forms and migration modes in isolated epithelial cells", Artificial Life and Robotics, vol.25, pp.523-528, 2020. [link]
  2. Y. Ikeda, P. Jurica, H. Kimura, H. Takagi, Z.R. Struzik, K. Kiyono,* Y. Arata, Y. Sako, "C. elegans episodic swimming is driven by multifractal kinetics", Scientific Reports, vol.10,14775, 2020. [link]
  3. K. Shinha, W. Nihei, *H. Kimura, "A microfluidic probe integrated device for spatiotemporal 3D chemical stimulation in cells", Micromachines, vol.11, no.7, 691, 2020. [link]
  4. K. Shinha, W. Nihei, T. Ono, R. Nakazato, *H. Kimura, "A pharmacokinetic-pharmacodynamic model based on multi-organ-on-a-chip for drug-drug interaction studies", Biomicrofluidics, vol.14, no.4, 44108, 2020. [link]
  5. M. Chikamori, H. Kimura, R. Inagi, J. Zhou, M. Nangaku, *T. Fujii, "Intracellular calcium response of primary cilia of tubular cells to modulated shear stress under oxidative stress", Biomicrofluidics, vol.14, no.4, 44102, 2020. [link]
  6. D. Kasahara, H. Sumiyoshi, H. Endo, T. Yanagawa, Y. Nakano, Y. Matsuki, S. Nakao, A. Kamiya, H. Kimura, *Y. Inagaki, "Visualization and Isolation of Zone-Specific Murine Hepatocytes That Maintain Distinct Cytochrome P450 Oxidase Expression in Primary Culture", Biochemical and Biophysical Research Communications, vol.528, no.3, pp.420-425, 2020. [link]
  7. K. Sasaki, K. Bandai, M. Takatsuka, M. Fujii, M. Takagi, R. Kita, S. Yagihara, H. Kimura, *N. Shinyashiki, "Heterogeneous solvent dielectric relaxation in polymer solutions of water and alcohols", Frontiers in Physics, vol.8, no.84, 2020. [link]
  8. H. Zhang, D. Sakagami, W. Huang, H. Kimura,* Y. Okamura, "Measurement and modelling of tensile moduli of polymer blend thin films with phase separated structures", Polymer, vol.190, 122233, 2020. [link]
  9. *Arata Y, Oshima T, Ikeda Y, Kimura H, Sako Y, "OP50, a bacterial strain conventionally used as food for laboratory maintenance of C. elegans, is a biofilm formation defective mutant", microPublication Biology, 2020. [link]

2019

  1. M. Komeya, H. Yamanaka, H. Sanjo, M. Yao, H. Nakamura, H. Kimura, T. Fujii, T. Sato, *T. Ogawa, "In vitro spermatogenesis in two-dimensionally spread mouse testis tissues", Reproductive Medicine and Biology, vol.18, no.4, pp.362-369, 2019. [link]
  2. S. Yokoyama, A. Otomo, S. Hadano, *H. Kimura, "An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons", Biomicrofluidics, vol.13, no.3, 34104, 2019. [link]
  3. *K. Arai, *K. Kabayama, J. Ono, H. Nakamura, H. Kimura, *K. Fukase,"Elucidation of isoflurane action mechanism on surgical diabetes using microfluidic device",AIP Conference Proceedings,vol.2067,pp20006,2019.[link]
  4. *M. Nishikawa, S. Yuri, H. Kimura, N. Yanagawa, M. Hamon, P. Hauser, L. Zhao, OD Jo,* N. Yanagawa, "Comprehensive analysis of chromatin signature and transcriptome uncovers functional lncRNAs expressed in nephron progenitor cells", Biochimica et Biophysica Acta – Gene Regulatory Mechanisms, vol.1862, no.1, pp.58-70, 2019. [link]

2018

  1. T. Ohkubo, H. Kinoshita, T. Maekawa, K. Kunida, H. Kimura, S. Kuroda, T. Fujii, "Development of a microfluidic cell culture and monitoring system for intracellular signaling studies", bioRxiv, 453100, 2018. [link]
  2. T. Hiraiwa, Y. Nakai, T. G Yamada, R. Tanimoto, H. Kimura, Y. Matsumoto, N. Miki,* N. Hiroi, A. Funahashi, "Quantitative analysis of sensitivity to a Wnt3a gradient in determination of the pole‐to‐pole axis of mitotic cells by using a microfluidic device", FEBS Open Bio, vol.8, no.12, PP1920-1935, 2018. [link]
  3. W. Huang, *Y. Sunami, H. Kimura, *S. Zhang, "Applications of Nanosheets in Frontier Cellular Research", Nanomaterials, vol.8, no.7, 519, 2018. [link]
  4. K. Kojima, H. Nakamura, M. Komeya, H. Yamanaka, Y. Makino, Y. Okada, T. Sato, T. Fujii, H. Kimura, *T. Ogawa, "Neonatal testis growth recreated in vitro by two-dimensional organ-spreading", Biotechnology and Bioengineering, vol.115, no.12, pp.3030-3041, 2018 [link]
  5. *M. Nishikawa, H. Kimura, N. Yanagawa, M. Hamon, P. Hauser, L. Zhao, OD Jo, *N. Yanagawa, "An optimal serum-free defined condition for in vitro culture of kidney organoids", Biochemical and Biophysical Research Communications, vol.501, no.4, pp.996-1002, 2018. [link]
  6. *H. Kimura, M. Nishikawa, N. Yanagawa, H. Nakamura, S. Miyamoto, M. Hamon, P. Hauser, L. Zhao, O. D. Jo, M. Komeya, T. Ogawa, *N. Yanagawa, "Effect of fluid shear stress on in vitro cultured ureteric bud cells in a pumpless microfluidic device", Biomicrofluidics, vol.12, no.4, 44107, 2018. [link]
  7. H. Yamanaka, M. Komeya, H. Nakamura, H. Sanjo, T. Sato, M. Yao,* H. Kimura,* T. Fujii, *T. Ogawa, "A monolayer microfluidic device supporting mouse spermatogenesis with improved visibility", Biochemical and Biophysical Research Communications, vol.500, no.4, pp.885-891, 2018. [link]
  8. K. Haneda, T. Oishi, H. Kimura, *T. Inazu, "Development of a microbioreactor for glycoconjugate synthesis", Bioorganic & Medicinal Chemistry, vol.26, no.8, pp.2092-2098, 2018. [link]
  9. *H. Kimura, Y. Sakai, T. Fujii, "Organ/Body-on-a-chip Based on Microfluidic Technology for Drug Discovery", Drug Metabolism and Pharmacokinetics, vol.33, no.1, pp.43-48, 2018. [link]

2017

  1. M. Komeya, K. Hayashi, H. Nakamura, H. Yamanaka, H. Sanjo, K. Kojima, T. Sato, M. Yao, *H. Kimura,* T. Fujii, *T. Ogawa, "Pumpless microfluidic system driven by hydrostatic pressure induces and maintains mouse spermatogenesis in vitro", Scientific Reports, vol.7, no.1, 15459, 2017. [link]
  2. 高橋翼, 中村寛子, *木村啓志, "精子選別機能集積型受精卵作出デバイスの開発",日本機械学会論文集, vol.83, no.850, 16, 2017. [link]
  3. 宮本隼佑, 亀崎勇暁, 諸星和, 喜多理王, *木村啓志, "ルードヴィヒ・ソレー効果を利用した重水分離システムの構築", 化学とマイクロ・ナノシステム学会会誌, vol.16, no.1, pp.47-48, 2017.
  4. Y. Nakano, S. Sachie, H. Sumiyoshi, K. Mikami, Y. Tanno, M. Sueoka, D. Kasahara, H. Kimura, T. Moro, A. Kamiya, K. Hozumi and *Y. Inagaki, "Identification of a Novel Alpha-Fetoprotein-Expressing Cell Population Induced by Jagged1/Notch Signal in Murine Fibrotic Liver", Hepatology Communications, vol.1, no.3, pp.215-229, 2017. [link]
  5. *K. M. Ganesh, M. Morohoshi, Y. Yasoda, S. Yokoyama, H. Kimura, K. Tsuchiya, "ZnO Based Microfluidic pH Sensor: A Versatile Approach for Quick Recognition of Circulating Tumor Cells in Blood", ACS Applied Materials & Interfaces, vol.9, no.6, pp.5193-5203, 2017. [link]

2016

  1. M.Horayama, K. Shinha, K. Kabayama, T. Fujii,* H. Kimura, "Spatial Chemical Stimulation Control in Microenvironment by Microfluidic Probe Integrated Device for Cell-Based Assay", PLOS ONE, vol.11, no.12, 2016. [link]
  2. *P.V. Hauser, M. Nishikawa, H. Kimura, T. Fujii, N. Yanagawa,"Controlled Tubulogenesis from Dispersed Ureteric Bud-derived Cells Using a Micropatterned Gel",Journal of Tissue Engineering and Regenerative Medicine,vol.10,no.9,762-771,2016.[Link]
  3. M. Komeya, H. Kimura, H. Nakamura, T. Yokonishi, T. Sato, K. Kojima, K. Hayashi, K. Katagiri, H. Yamanaka, H. Sanjo, M. Yao, S. Kamimura, K. Inoue, N. Ogonuki, A. Ogura, *T. Fujii, *T. Ogawa, "Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device", Scientific Reports, vol.6, 21472, 2016. [link]

2015

  1. L. Yang, Y. Okamura, *H. Kimura, "Surface Modification on Polydimethylsiloxane-based Microchannels with Fragmented Poly(L-lactic acid) Nanosheets", Biomicrofluidics, vol.9, 064108, 2015. [link]
  2. H. Kimura, T. Ikeda, H. Nakayama, Y. Sakai,* T. Fujii, "An On-chip Small Intestine-Liver Model for Pharmacokinetic Studies", Journal of Laboratory Automations, vol.20, no.3, pp.265-273, 2015. [link]
  3. H. Tozawa, T. Maekawa, H. Kimura, *T. Fujii, "A novel effect of parylene-based surface coating on HepG2 cell function", Materials Science and Engineering C, vol.46, pp.190-194, 2015. [link]

2014

  1. H. Nakayama, H. Kimura, T. Fujii, *Y. Sakai, "Image-based evaluations of distribution and cytotoxicity of Irinotecan (CPT-11) in a multi-compartment micro-cell coculture device", J. Biosci. Bioeng., vol.117(6), pp.756–762, 2014. [link]
  2. *M. Shinohara, H. Kimura, K. Montagne, K. Komori, T. Fujii, Y. Sakai, "Combination of microwell structures and direct oxygenation enables efficient and size-regulated aggregate formation of an insulin-secreting pancreatic beta-cell line", Biotechnol. Prog., vol.30(1), pp.178-187, 2014. [link]

2013

  1. X. He, H. Kimura,* T. Fujii, "A High-Throughput Device for Patterned Differentiation of Embryoid Bodies", Journal of Robotics and Mechatronics, vol.25, no.4, pp.623-630, 2013. [link]

2012

  1. J. Kawada, H. Kimura, H. Akutsu, Y. Sakai, *T. Fujii, "Spatiotemporally controlled delivery of soluble factors for stem cell differentiation", Lab on a Chip, vol.12, no.21, pp.4508-4515, 2012. [link]
  2. *M.M. Chowdhury, H. Kimura, T. Fujii, Y. Sakai, "Induction of alternative fate other than default neuronal fate of embryonic stem cells in a membrane-based two-chambered microbioreactor by cell-secreted BMP4", Biomicrofluidics, vol.6, 014117, 2012
  3. *K. Komori, S. Fujii, K. Montagne, H. Nakamura, H. Kimura, T. Otake, T. Fujii, Y. Sakai "Development of a Well-of-the-Well System-Based Embryo Culture Plate with an Oxygen Sensing Photoluminescent Probe", Sensors and Actuators B, vol.162, pp.278-283, 2012
  4. *T. Nojima, S. Kaneda, H. Kimura, T. Yamamoto, T. Fujii, "Application of Cell-free Expression of GFP for Evaluation of Microsystems", Frontiers in Bioscience, vol.17, pp.1931-1939, 2012

2011

  1. Y. Nakao, H. Kimura, Y. Sakai,* T. Fujii, "Bile canaliculi formation by aligning rat primary hepatocyte in a microfluidic device", Biomicrofluidics, vol.5, pp.022212-1-7, 2011
  2. T. Kurakazu, K. Kuribayashi-Shigetomi, Y. T. Matsunaga, H. Kimura, T. Fujii, Y. Sakai,* S. Takeuchi, "Selective Retrieval Method Using Electrolytically Generated Bubbles for Cell Array Applications", Sensors and Actuators B, vol.159, pp.229-233, 2011

2010

  1. H. Kimura, H. Takeyama, K. Komori, T. Yamamoto, Y. Sakai, *T. Fujii, "Microfluidic Device with Integrated Glucose Sensor for Cell-based Assay in Toxicology", Journal of Robotics and Mechatronics, vol.22, no.5, pp.594-600, 2010 [link]
  2. 木村啓志, 庄野裕基, Pereira-Rodrigues, 山本貴富喜, 酒井康行, 藤井輝夫, "オンチップグルコースセンサによる細胞活性オンライン計測の検討", 電気学会論文誌E, vol.130, no.10, pp.476-483, 2010. [link]
  3. *M.M. Chowdhury, T. Katsuda, K. Montagne, H. Kimura, K. Nobuhiko, H. Akutsu, T. Ochiya, T. Fujii, Y. Sakai, "Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor", Biomed Microdevices, vol.12, no.6, pp.1097-1105, 2010. [link]

2009

  1. H. Kimura, H. Nakamura, T. Akai, T. Yamamoto, H. Hattori, Y. Sakai, *T. Fujii, "On-chip Individual Embryo Coculture with Microporous Membrane-supported Endometrial Cells", IEEE Transactions on NanoBioscience, vol.8, no.4, pp.318-324, 2009(Chemical Biology (2008, issue 6)にも掲載). [link]
  2. 木村啓志, 中山秀謹, 山本貴富喜, 酒井康行, 藤井輝夫, "体内毒性試験へ向けたオンチップ小腸-肝臓由来細胞共培養システムの開発", 電気学会論文誌E, 129, no.8, pp.252-258, 2009. [link]
  3. 木村啓志, 中村寛子, 岩井孝介, 山本貴富喜, 竹内昌治, 藤井輝夫, 酒井康行, "ダイナミックマイクロアレイを用いた受精卵操作の自動化の試み", 電気学会論文誌E, 129, no.8, pp.245-251, 2009. [link]

2008

  1. *T. Nojima, T. Yamamoto, H. Kimura, T. Fujii, "Polymerase chain reaction-based biochemical logic gate coupled with cell-free transcription/ translation of green fluorescent protein as a report gate", Chemical Communications, vol.28, no.32, pp.3771-3773, 2008. [link]
  2. *T. Nojima, H. Kimura, T. Fujii, "Cell-free Protein Synthesis Conducted by Template DNA with Repetitive Sequence", Chemistry Letters, vol.37, no.6, pp.648-649, 2008. [link]
  3. H. Kimura, T. Yamamoto, H. Sakai, Y. Sakai, *T. Fujii, "An Integrated Microfluidic System for Long-term Perfusion Culture and On-line Monitoring of Intestinal Tissue Models", Lab on a Chip, vol.8, no.5, pp.741-746, 2008, May. [link]

2007

  1. H. Kimura, M. Nishikawa, T. Yamamoto, Y. Sakai, *T. Fujii, "Microfluidic Perfusion Culture of Human Hepatocytes", Journal of Robotics and Mechatronics, vol.19, no.5, pp.550-556, 2007. [link]
  2. *H. Nakayama, H. Kimura, K. Komori, T. Fujii Y. Sakai, "Development of a Multi-Compartment Micro-Cell Culture Device as a Future on-Chip Human: Fabrication of a Three-Compartment Device and Immobilization of Rat Mature Adipocytes for the Evaluation of Chemical Distributions", Journal of Robotics and Mechatronics, vol.19, no.5, pp.544-549, 2007. [link]